tricyclic

This chemical class of drugs usually refers to a group of antidepressants (and a few other drugs) sharing similar side effects and a triple ring molecular structure.

Also: TCA

• Secondary amines: desipramine, nortriptyline, protriptyline
• Tertiary amines: amitriptyline, clomipramine, doxepin, imipramine, trimipramine

Stephen Stahl's Clinical Pearls* (Consult your physician before making any change in your treatment.)

• Inexpensive.
• Just as effective as modern antidepressants.
• Possibly more effective in severe depression.
• Maprotiline (Ludiomil): increased seizures; norepinephrine selective.
• Amoxapine (Ascendin): neuroleptic properties; 5HT2 antagonist.
• Desipramine (Norpramine): norepinehrine selective.
• Clomipramine (Anafranil): most potent 5HT reuptake blocker of the TCAs; potent NE, too; effective in obsessive compulsive disorder; increased seizures at high doses

*Reprinted with permission from: Stahl, Stephen M Psychopharmacology of Antidepressants Paperback 1997 Martin Dunitz, Ltd & Blackwell Science You cannot fully appreciate this book until you have seen the extraordinary illustrations of every aspect of this area of psychopharmacology and neurochemistry. Loaded with practical clinical "pearls."

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