The brain adapts to use of alcohol and
some other drugs in such a way that symptoms may result when the substance is reduced or discontinued,
leading to diagnosis of this Substance-Related
Disorder. This
varies in intensity from no detectable symptoms to extreme discomfort with opioidwithdrawal.
(1) cessation of (or reduction in) opioid
use that has been heavy and prolonged (several weeks or longer)
(2) administration of an opioid antagonist
after a period of opioid use
B. Three (or more) of the following, developing within minutes to several days after Criterion A:
(1) dysphoric mood
(2) nausea or vomiting
(3) muscle aches
(4) lacrimation or rhinorrhea
(5) pupillary dilation, piloerection, or sweating
(6) diarrhea
(7) yawning
(8) fever
(9) Insomnia
C. The symptoms in Criterion B cause clinically significant distress or impairment in social, occupational, or other important areas of functioning.
D. The symptoms are not due to a general medical condition and are not better accounted for by another
mental disorder.