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psychopathology: reward deficiency syndrome


This term coined by Kenneth Blum postulates that a chemical imbalance present in some individuals replaces the normal positive emotions usually associated with safety and satiety with negative emotions such as anxiety and may explain certain mental disorders involving compulsive or impulsive behaviors, including substance use disorders.

Also: self-medication hypothesis

Blum, K, Cull, JG, Braverman, ER, Comings, DE. Reward deficiency syndrome. Am Sci. 1996; 84:132-145.



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