drug: sertindole
U.S. Preparations:
Preparations Outside U.S.:
Stephen Stahl's Clinical Pearls* (Consult your physician before making any change in
your treatment.)
- Prolongs QTc on EKG.
- Currently 'on hold' from marketing until relationship of QTc prolongation to ventricular
arrhythmias and sudden deaths clarified.
- Before withdrawal from marketing, pre-treatment EKG was recommended.
- Contraindicated in patients with prolonged QT intervals, with significant cardiac
disease, uncorrected hypokalemia, and concomitant use of other drugs that prolong the QT
interval
- Accepted as efficacious for treatment of schizophrenia
and bipolar disorders
- Anecdotal reports of use in children, and treatment-refractory cases, and for
positive symptoms of psychosis in disorders other than schizophrenia
- May cause less weight gain than other antipsychotics.
- Never say never, but essentially no EPS at any dose.
- Can cause nasal congestion and decreased ejaculatory volume.
Books and Other
Media:
Follow the hypertext link to purchase items. |
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*Reprinted with permission from: Stahl, Stephen M Psychopharmacology
of Antipsychotics Paperback 1999 Martin Dunitz, Ltd
You cannot fully appreciate this book until you have seen the extraordinary
illustrations of every aspect of this area of psychopharmacology and
neurochemistry. Loaded with practical clinical "pearls."
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