The National Institute of Mental Health Research Domain Criteria (RDoC)
In draft research domain criteria, a Construct of a Negative Valence System
"Activation of the brain’s defensive motivational system to promote behaviors that protect the organism from perceived danger. Normal fear involves a pattern of adaptive responses to conditioned or unconditioned threat stimuli (exteroceptive or interoceptive). Fear can involve internal representations and cognitive processing, and can be modulated by a variety of factors."
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